Table 1.
Selected miRNAs showing differential concentration changes between Normal and Overt patients
| Starting fraction | miRNA | NormAVE (log2CPM) | OvertAVE (log2CPM) | Log2FC | P |
|---|---|---|---|---|---|
| Urine | hsa-miR-130a-3p ♂ | 8.80 | 10.62 | 1.82 | 0.0238 |
| hsa-miR-142-3p | 8.20 | 10.35 | 2.16 | 0.0223 | |
| hsa-miR-223-3p | 11.33 | 13.85 | 2.52 | 0.0498 | |
| hsa-miR-22-3p | 11.87 | 13.29 | 1.42 | 0.0289 | |
| hsa-miR-320a-3p | 11.81 | 12.97 | 1.16 | 0.0332 | |
| EV (selected) | hsa-miR-941-1-3p | 9.71 | 6.01 | −3.70 | 0.0083 |
| hsa-miR-9-1-3p | 7.53 | 9.59 | 2.05 | 0.0479 | |
| hsa-let-7c-5p | 9.31 | 11.33 | 2.03 | 0.0050 | |
| hsa-miR-125b-1-5p | 11.48 | 13.34 | 1.86 | 0.0067 | |
| hsa-miR-486-1-5p | 15.05 | 13.26 | −1.79 | 0.0066 | |
| hsa-miR-144-3p | 11.98 | 10.24 | −1.75 | 0.0108 | |
| hsa-miR-30a-5p | 12.82 | 14.46 | 1.65 | 0.0400 | |
| hsa-miR-125a-5p | 10.97 | 12.36 | 1.39 | 0.0146 | |
| hsa-miR-30c-1-5p | 12.25 | 13.56 | 1.31 | 0.0450 | |
| hsa-miR-29b-1-3p ♂ | 9.99 | 11.28 | 1.29 | 0.0048 | |
| hsa-miR-99b-5p | 10.01 | 11.22 | 1.21 | 0.0246 | |
| hsa-miR-23b-3p | 11.10 | 12.30 | 1.20 | 0.0047 | |
| hsa-let-7a-1-5p | 13.37 | 14.55 | 1.18 | 0.0179 | |
| hsa-miR-26a-1-5p | 13.95 | 15.10 | 1.15 | 0.0023 | |
| hsa-miR-451a-5p | 17.85 | 16.70 | −1.15 | 0.0036 | |
| hsa-miR-27b-3p | 12.42 | 13.55 | 1.14 | 0.0164 | |
| hsa-miR-99a-5p | 10.60 | 11.70 | 1.10 | 0.0431 | |
| hsa-miR-26b-5p | 12.36 | 13.25 | 0.90 | 0.0002 | |
| hsa-miR-29c-3p | 12.20 | 13.07 | 0.86 | 0.0066 | |
| hsa-miR-363-3p | 10.30 | 9.54 | −0.76 | 0.0233 | |
| hsa-miR-185-5p | 7.93 | 5.40 | −0.67 | 0.0299 |
CPM, counts per million; EV, extracellular vesicle; miRNA, microRNA.
♂ (male) or ♀ (female) designates gender-specific enrichment for a given miRNAs. See Supplementary Table S3 for additional details.