Table 5.
miRNAs identified in this work that are associated with kidney function and/or diabetes
| miRNA | Kidney function | Diabetes function | Targeted pathways (validated) |
|---|---|---|---|
| hsa-let-7a-1-5p | LN, RCC, DN | DN | TGF-β (TGFBRI) |
| hsa-let-7c-5p | Rfib, ESRD | T1D (ESRD) | TGF-β (TGF-βRI) |
| hsa-miR-101-1-3p | AKI | – | – |
| hsa-miR-10a-5p | AKI,AKR | T2D (Glucose regulation) | cAMP (CREB1) |
| hsa-miR-10b-5p | RCC, AKR, AKI | Insulin resistance | Apoptosis (BCL2L11) |
| hsa-miR-122-5p | RCC | T2D (insulin resistance, obesity) | – |
| hsa-miR-124-1-3p | RCC | T2D (Glucagon, gastric bypass treatment) | – |
| hsa-miR-125a-5p | PCKD, DN | T2D,DN | IL-6R |
| hsa-miR-125b-1-5p | CKD, AKI | T1D (β-cell) | – |
| hsa-miR-130a-3p | DN | T1D | – |
| hsa-miR-133a-1-3p | – | T1D (β-cell) | FoxO/AMPK |
| hsa-miR-141-3p | RCC, DN | DN, Obesity-induced DM | PTEN (PTEN), TGF-β (ZEB1/2), IGF2 |
| hsa-miR-142-3p | AKI, AKR | T2D | TGF-β (TGFβRI) |
| hsa-miR-144-3p | IgA-N | T2D (Micro-vascular) | – |
| hsa-miR-148a-3p | LN-RD | T2D (β-cell) | PTEN (PTEN) |
| hsa-miR-152-3p | – | T2D (Insulin) | PTEN (PTEN) |
| hsa-miR-181b-1-5p | AKR, Nephron development | Glucose homeostasis, insulin resistance | Six2 |
| hsa-miR-182-5p | AKI, PKD | T2D (Insulin) | – |
| hsa-miR-183-5p | – | T2D (β-cell) | – |
| hsa-miR-185-5p | AKR | β-cell | Cytokine/IGF (SOCS3) |
| hsa-miR-188-5p | AKI, RIRI | – | – |
| hsa-miR-192-5p | AKI, RIRI, DN | T2D (β-cell), DN | – |
| hsa-miR-197-3p | – | Glycemic impairment | – |
| hsa-miR-200a-3p | Rfib, DN | DN, insulin | TGF-β (TGFβRI), IGF |
| hsa-miR-200c-3p | Glomerular cell function | T2D (Endo) | TGF-β (ZEB1/2) |
| hsa-miR-21-5p | Rfib, DN, IgA-N | T1D, T2D | TGF-β (SMAD7), PTEN (PTEN) |
| hsa-miR-22-3p | Rfib | T1D | TGF-β (BMP-7,6) |
| hsa-miR-23b-3p | RCC | T1D (β-cell) | PTEN (PTEN), Apoptosis (DP5) |
| hsa-miR-26a-1-5p | Podocyte injury, LN-RD, DN | T2D (Glucose/Insulin) | IGF (GSK3B), TGF-β (CTGF) |
| hsa-miR-26b-5p | AKI | T2D (β-cell- Insulin) | PTEN (PTEN) |
| hsa-miR-27b-3p | Glomerular injury | T2D (Islet) | TGF-B (gremlin 1) |
| hsa-miR-28-3p | RCC, DN | T1D (DN), T2D | – |
| hsa-miR-29b-1-3p | Rfib | T2D (Hyperglycemia) | – |
| hsa-miR-29c-3p | ESRD | T1D (ESRD) | TGF-β (targeted by) |
| hsa-miR-30a-5p | AKI, NS | T2D (Glucose, β-cell) | Notch (Notch1) |
| hsa-miR-30b-5p | LN-RD | β-cell dysfunction | – |
| hsa-miR-30c-1-5p | AKI, DN | DN | TGF-β (CTGF) |
| hsa-miR-30d-5p | AKI, PKD | T2D, β-cells (insulin) | Insulin (MAP4K4) |
| hsa-miR-31-5p | PCKD | T1D (serum), T2D (micro-vascular) | – |
| hsa-miR-335-5p | Renal senescence, DN | T1D (DN) | SOD2 |
| hsa-miR-342-3p | AKI | T1D,T2D (PBMCs) | – |
| hsa-miR-362-5p | RIRI | GDM | – |
| hsa-miR-363-3p | DN | T1D (DN) | – |
| hsa-miR-373-3p | DN | T1D (DN) | – |
| hsa-miR-451a-5p | DN | DN | – |
| hsa-miR-486-1-5p | DN, CKD, AKI, IgA-N | T2D, T1D (DN) | – |
| hsa-miR-660-5p | DN | T1D (DN) | – |
| hsa-miR-9-1-3p | – | T1D (serum) | – |
| hsa-miR-941-1-3p | – | – | Insulin (9) |
| hsa-miR-96-5p | PKD, RCC | T2D, β-cells (insulin) | IGF (synaptotagmin-like 4) |
| hsa-miR-99a-5p | AKR,RCC | Glucose/insulin regulation | mTOR |
| hsa-miR-99b-5p | AKR | T2D (IGT) | TGF-β (EMT) |
AKR, Acute Kidney Rejection/Renal Graft Rejection; AKI, acute kidney injury; CKD, chronic kidney disease; DIKD, drug induced kidney damage, DN, diabetic nephropathy; Endo, endothelial dysfunction; EMT, epithelial–mesenchymal transition; EndMT, endothelial-mesenchymal transition; ESRD, end-stage renal disease; GD, gestational diabetes mellitus; IgA-N, IgA nephropathy; IGF, insulin-like growth factor; IGT, impaired glucose tolerance; LN-RD, lupus nephritis induced renal damage; MA, microalbuminuria; miRNA, microRNA; NS, nephrotic syndrome; PCKD, poly-cystic kidney disease; PKD, progressive kidney disease; PTEN, phosphatase and tensin homolog; RCC, renal cell carcinoma; Rfib, renal fibrosis: RIRI, renal ischemia-reperfusion injury; TGF, transforming growth factor; T1D, type 1 diabetes mellitus; T2D), type 2 diabetes mellitus.
See references 23, 24,40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118, 119, 120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144.