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. 2018 May 24;9:611. doi: 10.3389/fphys.2018.00611

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Copyright © 2018 Damiano, Sasso, Accetta, Monda, De Luca, Pavone, Belfiore, Santillo and Mondola.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Activation of ERK1-2 and AKT trasductional pathways in presence of SOD1^wt and SOD1^G93A in SK-N-BE cells. Western blotting analysis of P-ERK (A) and P-AKT (B) in cells incubated with 400 ng/ml of SOD1^wt and SOD1^G93A for 10 and 30 min. The histograms show the mean values (+SE) evaluated by densitometric analysis of three independent experiments. The results were normalized to ERK1-2 and AKT respectively. ^∗p < 0.05 vs. Ctr; ^∗∗p < 0.001 vs. Ctr; ^#p < 0.05 vs. 10 min SOD1^wt; ^##p < 0.001 vs. 10 min SOD1^wt; ^ςp < 0.05 vs. 30 min SOD1^wt.