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. 2018 May 24;9:611. doi: 10.3389/fphys.2018.00611

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Copyright © 2018 Damiano, Sasso, Accetta, Monda, De Luca, Pavone, Belfiore, Santillo and Mondola.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of SOD1^wt and mutated SOD1^G93A on intracellular calcium levels in neuroblastoma SK-N-BE cells (A) and in NSC-34 cells (B). The data are compared with control and with carbachol-induced intracellular calcium increase (positive control). The graphs on the left show the mean ± SEM values (n = 6) relative to control of the indicated time points. The histograms on the right show the values of 10 s point and the relative ANOVA analysis. ^∗p < 0.001 vs. Ctr; ^#p < 0.01 vs. SOD^wt.