Table 2.
The baseline study population characteristics according to the quartile of urinary 8-oxoGuo: The Renal Iohexol Clearance Survey Follow-Up Study
| Baseline characteristics | Quartile of 8-oxoGuo, range (nmol/mmol creatinine) |
P for linear trenda | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Quartile 1 (n = 397) | Quartile 2 (n = 398) | Quartile 3 (n = 398) | Quartile 4 (n = 398) | ||||||
| (0.73–2.68) | (2.69–3.45) | (3.46–4.44) | (4.45–13.4) | ||||||
| Men, % | 59.4 | 52.8 | 42.5 | 42.2 | <0.001 | ||||
| Age baseline, yr | 57.0 | (3.8) | 58.1 | (3.8) | 58.5 | (3.8) | 58.6 | (3.8) | <0.001 |
| Body mass index, kg/m2 | 26.5 | (3.9) | 27.0 | (3.9) | 27.6 | (3.9) | 27.7 | (3.9) | <0.001 |
| GFR,b ml/min per 1.73 m2 | 94.4 | (13.9) | 93.4 | (13.8) | 92.8 | (13.8) | 94.5 | (13.8) | 0.23 |
| Systolic blood pressure, mm Hg | 129.2 | (17.1) | 129.8 | (17.0) | 130.0 | (17.1) | 128.7 | (17.1) | 0.69 |
| Diastolic blood pressure, mm Hg | 83.5 | (9.4) | 83.4 | (9.4) | 83.5 | (9.4) | 83.0 | (9.4) | 0.89 |
| Fasting glucose, mmol/l | 5.25 | (0.46) | 5.30 | (0.46) | 5.34 | (0.46) | 5.39 | (0.46) | <0.001 |
| Hemoglobin A1c, % | 5.51 | (0.33) | 5.52 | (0.33) | 5.57 | (0.33) | 5.55 | (0.33) | 0.05 |
| HDL-cholesterol, mmol/l | 1.57 | (0.40) | 1.56 | (0.39) | 1.52 | (0.40) | 1.49 | (0.40) | 0.03 |
| LDL-cholesterol, mmol/l | 3.57 | (0.86) | 3.68 | (0.86) | 3.69 | (0.86) | 3.72 | (0.86) | 0.07 |
| High-sensitivity C-reactive protein, mg/l | 1.03 | (0.90–1.17) | 1.16 | (1.03–1.30) | 1.17 | (1.04–1.31) | 1.39 | (1.25–1.53) | 0.003 |
| Triglycerides, mmol/l | 1.00 | (0.90–1.10) | 1.00 | (0.90–1.10) | 1.10 | (1.00–1.20) | 1.10 | (1.00–1.20) | 0.29 |
| Urinary albumin-creatinine ratio, mg/mmol | 0.16 | (0.10–0.22) | 0.25 | (0.19–0.31) | 0.26 | (0.20–0.31) | 0.22 | (0.16–0.28) | 0.11 |
| ACEi, % | 3.4 | 4.9 | 2.8 | 3.5 | 0.56 | ||||
| ARB, % | 12.3 | 17.6 | 15.8 | 16.1 | 0.25 | ||||
| Current smoker, % | 12.2 | 22.2 | 19.3 | 28.0 | <0.001 | ||||
| Alcohol consumption, % | 36.7 | 33.5 | 33.5 | 27.9 | 0.12 | ||||
ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; GFR, glomerular filtration rate; HDL, high-density lipoprotein; LDL, low-density.
lipoprotein; 8-oxoGuo, 8-oxo-7,8-dihydroguanosine.
Numbers were adjusted for sex and are presented as mean (SD), median (interquartile range), and percent.
a
Linear trend over increasing quartiles of urinary 8-oxoGuo was adjusted for gender.
b
GFR was measured by iohexol clearance.