Table 3.
The association of urinary 8-oxodG and 8-oxoGuo with measured GFR change rates in mixed models: The Renal Iohexol Clearance Survey Follow-Up Study
| Risk factora | Model 1 unadjusted |
Model 2 adjusted for sex, age, weight, and height |
Model 3 fully adjustedb |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Estimate (ml/min per 1.73 m2 per year) | (95% CI) | P | Estimate (ml/min per 1.73 m2 per year) | (95% CI) | P | Estimate (ml/min per 1.73 m2 per year) | (95% CI) | P | |
| Urinary 8-oxodG | |||||||||
| Per 1 nmol/mmol | −0.12 | (−0.29 to 0.06) | 0.19 | −0.09 | (−0.27 to 0.09) | 0.35 | −0.02 | (−0.20 to 0.16) | 0.82 |
| Quartile 1 | 0.00 | (ref) | 0.00 | (ref) | 0.00 | (ref) | |||
| Quartile 2 | −0.12 | (−0.42 to 0.18) | −0.11 | (−0.40 to 0.19) | −0.08 | (−0.37 to 0.21) | |||
| Quartile 3 | −0.16 | (−0.46 to 0.13) | −0.14 | (−0.44 to 0.16) | −0.09 | (−0.39 to 0.21) | |||
| Quartile 4 | −0.24 | (−0.54 to 0.05) | −0.20 | (−0.51 to 0.11) | −0.08 | (−0.38 to 0.23) | |||
| (0.45c) | (0.64c) | (0.88c) | |||||||
| Q4 versus Q1–Q3d | −0.15 | (−0.39 to 0.09) | 0.23 | −0.11 | (−0.36 to 0.14) | 0.39 | −0.02 | (−0.26 to 0.23) | 0.89 |
| Urinary 8-oxoGuo | |||||||||
| Per 1 nmol/mmol | −0.04 | (−0.11 to 0.03) | 0.28 | −0.02 | (−0.10 to 0.05) | 0.52 | 0.0003 | (−0.07 to 0.08) | 0.99 |
| Quartile 1 | 0.00 | (ref) | 0.00 | (ref) | 0.00 | (ref) | |||
| Quartile 2 | −0.09 | (−0.39 to 0.20) | −0.06 | (−0.35 to 0.24) | −0.02 | (−0.32 to 0.27) | |||
| Quartile 3 | 0.05 | (−0.24 to 0.35) | 0.10 | (−0.19 to 0.40) | 0.17 | (−0.12 to 0.47) | |||
| Quartile 4 | −0.21 | (−0.51 to 0.09) | −0.15 | (−0.45 to 0.15) | −0.02 | (−0.32 to 0.29) | |||
| (0.34c) | (0.39c) | (0.56c) | |||||||
| Q4 versus Q1–Q3d | −0.20 | (−0.44 to 0.05) | 0.12 | −0.17 | (−0.41 to 0.08) | 0.18 | −0.07 | (−0.32 to 0.17) | 0.56 |
CI, confidence interval; 8-oxodG, 8-oxo-7,8-dihydro-2′-deoxyguanosine; 8-oxoGuo, 8-oxo-7,8-dihydroguanosine.
8-oxodG and 8-oxoGuo were normalized for urinary creatinine.
Adjusted for sex, baseline age, height, body weight, diastolic blood pressure, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting triglycerides, hemoglobin A1c, high-sensitivity C-reactive protein; a dichotomous variable for the weekly use of alcohol; number of cigarettes currently smoked; log urine albumin-to-creatinine ratio; and the use of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker.
Wald test for linear trend was applied.
Persons with 8-oxodG or 8-oxoGuo in the highest quartile compared with the lowest quartiles.