Table 4.
The association of urinary 8-oxodG and 8-oxoGuo with the risk of low-grade albuminuria in logistic regression models: The Renal Iohexol Clearance Survey Follow-Up Study
| Low-grade albuminuriaa | Unadjusted |
Adjusted for sex, and baseline age, weight, and height |
Fully adjustedb |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Odds ratio | (95% CI) | P | Odds ratio | (95% CI) | P | Odds ratio | (95% CI) | P | |
| Urinary 8-oxodG | |||||||||
| Per 1 nmol/mmol | 1.53 | (1.04–2.26) | 0.03 | 1.33 | (0.88–2.01) | 0.18 | 1.24 | (0.80–1.90) | 0.34 |
| Quartile 1 | (ref) | (ref) | (ref) | ||||||
| Quartile 2 | 0.88 | (0.37–2.11) | 0.81 | (0.34–1.95) | 0.75 | (0.31–1.81) | |||
| Quartile 3 | 1.28 | (0.57–2.87) | 1.08 | (0.48–2.46) | 0.92 | (0.40–2.14) | |||
| Quartile 4 | 1.65 | (0.76–3.58) | 1.26 | (0.56–2.84) | 1.07 | (0.46–2.48) | |||
| (0.41c) | (0.76c) | (0.54c) | |||||||
| Q4 versus Q1–Q3d | 1.57 | (0.86–2.84) | 0.14 | 1.30 | (0.71–2.41) | 0.40 | 1.22 | (0.65–2.29) | 0.54 |
| Urinary 8-oxoGuo | |||||||||
| Per 1 nmol/mmol | 1.19 | (1.02–1.39) | 0.03 | 1.18 | (1.00–1.39) | 0.05 | 1.16 | (0.98–1.37) | 0.09 |
| Quartile 1 | (ref) | (ref) | (ref) | ||||||
| Quartile 2 | 1.18 | (0.47–2.94) | 1.12 | (0.45–2.82) | 1.07 | (0.42–2.72) | |||
| Quartile 3 | 1.22 | (0.49–3.05) | 1.16 | (0.46–2.93) | 1.14 | (0.45–2.93) | |||
| Quartile 4 | 2.99 | (1.36–6.57) | 2.87 | (1.28–6.44) | 2.84 | (1.23–6.54) | |||
| (0.009c) | (0.01c) | (0.02c) | |||||||
| Q4 versus Q1–Q3d | 2.64 | (1.50–4.65) | 0.001 | 2.62 | (1.48–4.65) | 0.001 | 2.64 | (1.46–4.80) | 0.001 |
CI, confidence interval; 8-oxodG, 8-oxo-7,8-dihydro-2′-deoxyguanosine; 8-oxoGuo, 8-oxo-7,8-dihydroguanosine.
8-oxodG and 8-oxoGuo were normalized for urinary creatinine.
Low-grade albuminuria was defined as a urinary albumine-creatinine ratio >1.13 mg/mmol (>10 mg/g).
Adjusted for sex, baseline age, height, body weight, diastolic blood pressure, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, fasting triglycerides, hemogloin A1c, high-sensitivity C-reactive protein; a dichotomous variable for the weekly use of alcohol; number of cigarettes currently smoked; the use of an angiotensin-converting enzyme inhibitor and angiotensin receptor blocker; and baseline measured glomerular filtration rate.
Wald test for linear trend was applied.
Persons with 8-oxodG or 8-oxoGuo in the highest quartile compared with the lowest quartiles.