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Grimelius silver reaction at the EM level in human fetal small bowel mucosa (left), pulmonary tumorlet (center) and argyrophilic scirrhous gastric cancer (right) in paraffin sections. Argyrophilic reactions are focused on the cored granules in the respective neuroendocrine-type cells. Silver grains are clustered in the peripheral halo area, and this is particularly evident in small-sized granules in pulmonary tumorlet. Background staining is minimal. Bars = 1 μm.
