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Ectopic insulinoma of the duodenum (left) and calcitonin-positive large cell neuroendocrine carcinoma of the lung (right) immunostained in paraffin sections and processed for EM observation. The cytoplasm is abundant in round-shaped granules immunoreactive for insulin or calcitonin and measuring around 200 nm. The margin of the positively signaled granules is obscure in both cases. The preservation of background fine morphology is poor. Bars = 1 μm (left) and 2 μm (right).
