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. 2001 Oct 2;98(21):12072–12077. doi: 10.1073/pnas.211053698

Figure 4.

Figure 4

Tumor growth stimulated by fibroblasts. Nude mice were injected with epithelial cells alone (Control) or presenescent (Presn), senescent (Sen), or hTERT-immortalized (Telom) fibroblasts. At the indicated intervals (Days), tumor size was measured as described in Materials and Methods. The number of animals per group (n) is indicated. The last point on each line indicates when tumors were excised for histology. (A) HaCAT cells (1.5 × 106) alone or with 1.5 × 106 WI-38 fibroblasts. Shown are results from two experiments. The incidence of tumors >10 mm3 and average tumor size were greater in the senescent group (P < 0.05). (B) SCp2 cells (1 × 106) alone or with 1 × 106 WI-38 cells. Tumor incidence was greater in the senescent group (P < 0.05). (C) Ha(Pk) cells (1.5 × 106) alone or with 1.5 × 106 WI-38 cells. (D) MDA231 cells (2.5 × 105) alone or with 1 × 106 WI-38 cells. Tumor size was greater in the senescent group (P < 0.01).