Table 2.
MMP-9, TIMP-1, and MMP-9/TIMP-1 ratio as diagnostic biomarkers of sepsis.
| AUC-ROC (95% CI) | |||
|---|---|---|---|
| MMP-9 | TIMP-1 | MMP-9/TIMP-1 ratio | |
| Nonoperated controls versus operated controls | |||
| 0 h | 0.798 (0.702–0.895)∗ | 0.584 (0.465–0.704) | 0.761 (0.664–0.858)∗ |
| Sepsis versus nonoperated controls | |||
| 0 h | 0.675 (0.561–0.789)∗ | 0.940 (0.889–0.991)∗ | 0.924 (0.873–0.975)∗ |
| 24 h | 0.640 (0.511–0.769)∗ | 0.972 (0.941–1.004)∗ | 0.929 (0.878–0.980)∗ |
| 48 h | 0.593 (0.450–0.736) | 0.929 (0.862–0.997)∗ | 0.914 (0.853–0.975)∗ |
| 72 h | 0.591 (0.417–0.765) | 0.951 (0.892–1.006)∗ | 0.901 (0.821–0.980)∗ |
| 96 h | 0.646 (0.457–0.826) | 0.925 (0.825–1.026)∗ | 0.911 (0.825–0.997)∗ |
| Sepsis versus operated controls | |||
| 0 h | 0.541 (0.418–0.664) | 0.854 (0.778–0.930)∗ | 0.788 (0.697–0.879)∗ |
| 24 h | 0.513 (0.372–0.653) | 0.870 (0.797–0.943)∗ | 0.753 (0.650–0.855)∗ |
| 48 h | 0.570 (0.415–0.724) | 0.820 (0.728–0.913)∗ | 0.718 (0.605–0.832)∗ |
| 72 h | 0.523 (0.342–0.703) | 0.857 (0.768–0.913)∗ | 0.724 (0.593–0.854)∗ |
| 96 h | 0.514 (0.307–0.721) | 0.845 (0.738–0.952)∗ | 0.750 (0.612–0.888)∗ |
Data are presented as AUC-ROC (95% CI). ∗p < 0.05. AUC-ROC: area under receiver operating characteristic curve; MMP-9: matrix metalloproteinase-9; TIMP-1: tissue inhibitor of matrix metalloproteinase-1.