Table 3.
Correlation analysis.
| MMP-9 | TIMP-1 | MMP-9/TIMP-1 ratio | |
|---|---|---|---|
| Disease severity scores | |||
| APACHE II | −0.099 | 0.107 | −0.116∗ |
| SOFA | −0.149∗∗ | 0.181∗∗ | −0.196∗∗ |
| Biomarkers of inflammation | |||
| WBC | 0.377∗∗ | 0.018 | 0.268∗∗ |
| CRP | −0.047 | 0.019 | −0.037 |
| PCT | −0.246∗∗ | 0.150 | −0.214∗∗ |
| Biomarkers of kidney injury | |||
| Urea | −0.154∗∗ | 0.103 | −0.167∗∗ |
| Creatinine | −0.187∗∗ | 0.153∗∗ | −0.234∗∗ |
| Serum NGAL | −0.089 | 0.271∗∗ | −0.203∗∗ |
| Urine NGAL | −0.277∗∗ | 0.197∗∗ | −0.338∗∗ |
| KIM-1 | 0.002 | 0.144∗∗ | −0.104 |
| Biomarkers of liver injury | |||
| AST | −0.145∗ | 0.236∗∗ | −0.210∗∗ |
| ALT | −0.051 | 0.148∗ | −0.097 |
| Total bilirubin | −0.290∗∗ | 0.102 | −0.266∗∗ |
| Direct bilirubin | −0.299∗∗ | 0.143 | −0.263∗∗ |
| Biomarkers of coagulation | |||
| Platelets | 0.371∗∗ | −0.103 | 0.329∗∗ |
| INR | −0.112 | 0.153∗ | −0.127 |
| aPTT | −0.143∗ | 0.102∗ | 0.135∗ |
| Biomarkers of metabolic disorders | |||
| Total protein | 0.113∗ | −0.109∗ | 0.120∗ |
| Glucose | −0.062 | 0.270∗∗ | −0.246∗∗ |
| Lactate | −0.211∗∗ | 0.263∗∗ | −0.275∗∗ |
Kendall's Tau-b correlation analysis. ∗∗The correlation is significant at the 0.01 level (2-tailed); ∗ the correlation is significant at the 0.05 level (2-tailed). MMP-9: matrix metalloproteinase-9; TIMP-1: tissue inhibitor of matrix metalloproteinase-1; APACHE II: Acute Physiology and Chronic Health Evaluation II score; SOFA: Sequential Organ Failure Assessment score; WBC: white blood cell; CRP: C-reactive protein; PCT: procalcitonin; NGAL: neutrophil gelatinase-associated lipocalin; KIM-1: kidney injury molecule-1; AST: aspartate aminotransferase; ALT: alanine aminotransferase; INR: international normalized ratio; aPTT: activated partial thromboplastin time.