Table 4.

Phenotypes of splenocytes from TRAMP mice before (onset group) or after 3-month treatment (both control and extract groups).

Phenotypes (%)	Onset (n = 5)	Control (n = 5)	Extract (n = 12)	P value (onset versus control)	P value (onset versus extract)	P value (control versus extract)
CD4	18.82 ± 2.18	16.6 ± 2.89	17.18 ± 2.85	0.2080	0.2714	0.7074
CD8	14.11 ± 3.18	8.29 ± 0.88	11.6 ± 3.32	0.0043	0.1713	0.0474
CD45R/B220	49.14 ± 19.26	66.2 ± 3.17	58.36 ± 12.48	0.0864	0.2539	0.1929
NK1.1	3.74 ± 0.82	2.22 ± 0.05	3.21 ± 1.46	0.0031	0.4619	0.1549
Mac3	9.85 ± 2.31	2.4 ± 0.57	7.34 ± 5.92	0.0001	0.3787	0.0872
CD11b	6.9 ± 1.09	4.98 ± 0.94	7.44 ± 2.58	0.0177	0.6582	0.0579

Phenotypes of splenocytes (CD4: CD4⁺ T cells; CD8: CD8⁺ T cells; CD45R: B cells; NK1.1: NK cells; Mac3: macrophages; CD11b: DCs) were determined by FACS analysis. Data are presented as mean ± SEM in each group, and were compared using two-tailed t-test.