Figure 1.

A₃AR overexpression in a skin lesion and PBMCs from psoriasis patients. (a) A₃AR expression level was evaluated in formalin-fixed paraffin-embedded representative skin lesion from psoriasis patient. A₃AR mRNA in the psoriatic skin lesion was compared to adjacent healthy skin tissue using RT-PCR. A₃AR was highly expressed in the skin lesion compared to the healthy tissue. (b) A₃AR protein expression level was analyzed using WB analysis in PBMCs from psoriasis patients (n = 48) compared with healthy subjects (n = 50). A significant (p = 0.0001) A₃AR upregulation is noted. (c) A₃AR mRNA expression level was tested in PBMCs from psoriasis patients compared to healthy subjects using real-time PCR.