Table 2.
In vitro antifungal susceptibility of eight antifungal agents against 134 Candida spp. isolated from Candida-associated denture stomatitis.
| Candida species/number of strains/antifungal drugs | MIC µg/mL | |||
|---|---|---|---|---|
| MIC range | MIC50 | MIC90 | GM | |
| All Candida species (134) | ||||
| FLC | 0.016–16 | 0.125 | 8 | 0.26 |
| ITC | 0.016–16 | 0.064 | 0.5 | 0.08 |
| VRC | 0.016–4 | 0.125 | 0.5 | 0.11 |
| AMB | 0.016–2 | 0.064 | 0.25 | 0.05 |
| CAS | 0.008–2 | 0.125 | 0.5 | 0.12 |
| TRB | 2–≥128 | 128 | >128 | 65.00 |
| POS | 0.032–0.5 | 0.016 | 0.125 | 0.03 |
| KET | 0.016–4 | 0.125 | 1 | 0.15 |
| C. albicans (84) | ||||
| FLC | 0.016–16 | 0.064 | 2 | 0.09 |
| ITC | 0.016–0.5 | 0.032 | 0.5 | 0.04 |
| VRC | 0.032–0.25 | 0.064 | 0.25 | 0.08 |
| AMB | 0.008–0.25 | 0.032 | 0.25 | 0.03 |
| CAS | 0.008–1 | 0.064 | 0.5 | 0.08 |
| TRB | 2–≥128 | 128 | 128 | 96.68 |
| POS | 0.032–0.5 | 0.016 | 0.032 | 0.01 |
| KET | 0.016–2 | 0.125 | 1 | 0.09 |
| C. glabrata (23) | ||||
| FLC | 0.25–≥16 | 4 | 64 | 5.24 |
| ITC | 0.125–0.5 | 0.25 | 0.5 | 0.26 |
| VRC | 0.125–2 | 0.25 | 0.5 | 0.24 |
| AMB | 0.032–0.5 | 0.032 | 0.5 | 0.07 |
| CAS | 0.008–2 | 0.5 | 1 | 0.51 |
| TRB | 8–>128 | 16 | 64 | 19.77 |
| POS | 0.125–0.5 | 0.125 | 0.5 | 0.19 |
| KET | 0.064–1 | 0.125 | 0.5 | 0.14 |
| C. tropicalis (16) | ||||
| FLC | 0.125–≥16 | 0.125 | 4 | 0.42 |
| ITC | 0.016–16 | 0.016 | 4 | 0.27 |
| VRC | 0.016–4 | 0.032 | 2 | 0.08 |
| AMB | 0.016–2 | 0.125 | 1 | 0.17 |
| CAS | 0.008–1 | 0.032 | 0.125 | 0.05 |
| TRB | 4–≥128 | 64 | 128 | 53.81 |
| POS | 0.016–0.25 | 0.032 | 0.25 | 0.05 |
| KET | 0.032–4 | 0.25 | 2 | 0.23 |
| C. parapsilosis (11) | ||||
| FLC | 0.25–4 | 0.25 | 2 | 0.46 |
| ITC | 0.125–8 | 0.25 | 4 | 0.46 |
| VRC | 0.25–2 | 0.25 | 1 | 0.41 |
| AMB | 0.016–2 | 0.25 | 1 | 0.19 |
| CAS | 0.008–2 | 0.25 | 1 | 0.41 |
| TRB | 4–≥128 | 128 | 128 | 49.74 |
| POS | 0.032–0.125 | 0.032 | 0.125 | 0.05 |
| KET | 0.125–2 | 0.125 | 1 | 0.25 |
FLC, fluconazole; ITC, itraconazole; VRC, voriconazole; AMB, amphotericin B; CAS, caspofungin; TRB, terbinafine; POS, posaconazole; KET, ketoconazole; GM, geometric mean; MIC, minimum inhibition concentration; MIC50 and MIC90, concentration at which 50% and 90% of the strains were inhibited, respectively.