Table 1.
Association between hyperoxemia and clinically relevant outcomes after myocardial infarction and cardiac arrest.
| Reference | Study design | Sample size | Hyperoxemia definition | Condition | Location | Conclusion |
|---|---|---|---|---|---|---|
| [20], Ranchordet al. | RCT | 136 | 6 L O2/min | STEMI | - | High-O2 therapy had no effect on mortality or infarct size |
|
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| [21], Spindelboeck et al. | Retrospective cohort | 1015 | PaO2> 40.0 kPa | Cardiac arrest | Pre-hospital | Higher hospital admission rates when during CPR |
|
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| [22], Vaahersalo et al. | Prospective cohort | 409 | PaO2> 40.0 kPa | Cardiac arrest | ICU | No association with different 12 month outcome |
|
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| [23], Ihle et al. | Retrospective cohort | 584 | PaO2> 40.0 kPa | Cardiac arrest | ICU | No association with in-hospital mortality |
|
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| [24], Helmerhorst et al. | Retrospective cohort | 5258 | PaO2 > 39.9 kPa | Cardiac arrest | ICU | Hyperoxia not associated with higher mortality rates |
|
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| [25], Bellomo et al. | Retrospective cohort | 12,108 | PaO2> 40.0 kPa | Cardiac arrest | ICU | No association with mortality |
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| [26], Chirst et al. | Retrospective cohort | 134 | - | Cardiac arrest | - | Hyperoxia in the first 60 minutes after return of circulation is associated with better survival rates |
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| [27], Lee et al. | Retrospective cohort | 213 | - | Cardiac arrest | - | Hypocarbia associated with in-hospital mortality. Hypoxemia and hyperoxemia associated with poor neurological outcome. |
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| [28], Kilgannon et al. | Retrospective cohort | 6,326 | PaO2> 40.0 kPa | Cardiac arrest | ICU | Higher mortality rates, even when compared to hypoxemia |
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| [29], Elmer et al. | Retrospective analysis of prospective registry | 184 | Severe: PaO2> 40.0 kPa Moderate/ probable: PaO2 13.5–39.9 kPa |
Cardiac arrest | ICU | Severe associated with higher in-hospital mortality. Moderate/probable was not but was associated with improved organ function after 24 hours. |
|
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| [30], Kilgannon et al. | Retrospective cohort | 4,459 | - | Cardiac arrest | ICU | Dose-dependent association with in-hospital mortality |
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| [31], Janz et al. | Post-hoc analysis of prospective cohort | 170 | - | Cardiac arrest | Cardiovascular care unit | Higher in-hospital mortality and poor neurological status on hospital discharge in survivors |
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| [32], Young et al. | RCT | 18 | - | Cardiac arrest | Prehospital | Study terminated early, because pre-hospital oxygen titration was not feasible. |