Table 2.
Summary estimates of subgroup analysis for miRNA in pancreatic cancer diagnosis.
| Subgroups | Number of studies | SEN (95% CI) | SPE (95% CI) | +LR (95% CI) | −LR (95% CI) | DOR (95% CI) | AUC (95% CI) |
|---|---|---|---|---|---|---|---|
| Source of patients | |||||||
| PDAC | 46 | 0.81 (0.79, 0.83) | 0.78 (0.76, 0.80) | 3.19 (2.54, 4.02) | 0.27 (0.21, 0.34) | 14.35 (9.62, 21.40) | 0.86 (0.82, 0.89) |
| PaC | 63 | 0.81 (0.79, 0.82) | 0.78 (0.76, 0.79) | 3.42 (2.89, 4.05) | 0.27 (0.23, 0.31) | 14.98 (11.31, 19.84) | 0.87 (0.84, 0.89) |
| Source of control | |||||||
| Healthy control | 58 | 0.82 (0.81, 0.83) | 0.76 (0.74, 0.78) | 3.21 (2.66, 3.87) | 0.26 (0.22, 0.31) | 14.29 (10.41, 19.60) | 0.86 (0.83, 0.88) |
| Disease control | 51 | 0.79 (0.78, 0.81) | 0.79 (0.78, 0.81) | 3.46 (2.84, 4.23) | 0.28 (0.23, 0.33) | 14.96 (10.63, 21.05) | 0.86 (0.83, 0.89) |
| Ethnicity | |||||||
| Asian | 65 | 0.78 (0.77, 0.80) | 0.76 (0.74, 0.78) | 3.02 (2.55, 3.57) | 0.30 (0.26, 0.34) | 11.95 (9.05, 15.78) | 0.84 (0.81, 0.86) |
| Caucasian | 44 | 0.84 (0.82, 0.85) | 0.80 (0.78, 0.82) | 3.91 (3.10, 4.92) | 0.23 (0.18, 0.29) | 20.23 (13.61, 30.09) | 0.88 (0.85, 0.91) |
| miRNA profiles | |||||||
| Single miRNA | 71 | 0.75 (0.74, 0.77) | 0.76 (0.74, 0.77) | 2.82 (2.41, 3.29) | 0.34 (0.30, 0.39) | 9.48 (7.44, 12.08) | 0.82 (0.79, 0.84) |
| Multiple miRNAs | 38 | 0.87 (0.86, 0.88) | 0.81 (0.79, 0.82) | 4.65 (3.62, 5.97) | 0.16 (0.13, 0.21) | 35.88 (22.92, 56.16) | 0.92 (0.89, 0.94) |
| Source of miRNA | |||||||
| Blood | 80 | 0.79 (0.78, 0.80) | 0.78 (0.76, 0.79) | 3.35 (2.92, 3.84) | 0.29 (0.25, 0.33) | 13.64 (10.74, 17.33) | 0.85 (0.83, 0.87) |
| Tissue | 13 | 0.90 (0.88, 0.92) | 0.90 (0.87, 0.92) | 7.14 (4.43, 11.50) | 0.09 (0.05, 0.19) | 96.13 (39.20, 235.77) | 0.96 (0.93, 0.98) |
| Fecal | 13 | 0.80 (0.76, 0.84) | 0.57 (0.49, 0.63) | 1.77 (1.28, 2.44) | 0.35 (0.23, 0.55) | 5.52 (2.67, 11.42) | 0.75 (0.66, 0.85) |
| Pancreatic juice | 3 | 0.79 (0.68, 0.88) | 0.60 (0.45, 0.74) | 1.87 (1.31, 2.68) | 0.34 (0.21, 0.57) | 5.77 (2.53, 13.15) | 0.76 (0.66, 0.85) |
| miRNA-21 | |||||||
| Yes | 24 | 0.85 (0.83, 0.87) | 0.83 (0.80, 0.86) | 4.76 (2.96, 7.66) | 0.19 (0.13, 0.28) | 30.24 (15.44, 59.21) | 0.91 (0.87, 0.95) |
| No | 85 | 0.80 (0.78, 0.81) | 0.77 (0.75, 0.78) | 3.06 (2.67, 3.50) | 0.29 (0.25, 0.33) | 12.31 (9.69, 15.65) | 0.84 (0.82, 0.86) |
| Overall | 109 | 0.81 (0.80, 0.82) | 0.78 (0.77, 0.79) | 3.32 (2.90, 3.80) | 0.27 (0.24, 0.31) | 14.56 (11.55, 18.34) | 0.86 (0.84, 0.88) |
SEN: sensitivity; SPE: specificity; +LR: positive likelihood ratio; −LR: negative likelihood ratio; DOR: diagnostic odds ratio; AUC: area under the curve; PDAC: pancreatic ductal adenocarcinoma.