Table 3.
Biomarkers of coagulation activation at baseline and at 3 and 6 months.
| CON (n=16) | n b | BIKE (n=19) | n b | MOD (n=31) | n b | VIG (n=24) | n b | p values | |
|---|---|---|---|---|---|---|---|---|---|
| ETP (nM·min)a | 0.314c, 0.413d, 0.555e | ||||||||
| Baseline | 1985 (1819; 2166) | 16 | 2049 (1803; 2328) | 18 | 1975 (1859; 2097) | 31 | 1883 (1750; 2026) | 22 | |
| 3 months | 2000 (1844; 2171) | 15 | 2143 (1957; 2346) | 16 | 1963 (1832; 2103) | 29 | 1970 (1849; 2094) | 24 | |
| 6 months | 2078 (1907; 2358) | 16 | 2108 (1884; 2358) | 16 | 1965 (1844; 2094) | 31 | 2008 (1858; 2126) | 24 | |
|
| |||||||||
| Time to peak (min) | 0.882c, 0.942d, 0.453e | ||||||||
| Baseline | 6.78 (6.26; 7.33) | 16 | 6.46 (5.78; 7.15) | 18 | 6.36 (5.97; 6.75) | 30 | 6.87 (6.23; 7.51) | 23 | |
| 3 months | 6.59 (5.97; 7.21) | 15 | 6.24 (5.70; 6.79) | 16 | 6.34 (5.93; 6.34) | 29 | 6.85 (6.28; 7.44) | 24 | |
| 6 months | 6.37 (5.66; 7.05) | 16 | 6.28 (5.67; 6.89) | 16 | 6.26 (5.84; 6.68) | 31 | 6.57 (5.96; 7.19) | 24 | |
|
| |||||||||
| Start tail (min)a | 0.934c, 0.490d, 0.993e | ||||||||
| Baseline | 26.7 (25.5; 27.9) | 16 | 26.9 (25.6; 28.2) | 18 | 26.5 (25.7; 27.2) | 31 | 26.6 (25.5; 27.5) | 22 | |
| 3 months | 27.0 (26.7; 28.4) | 15 | 27.5 (26.3; 28.6) | 16 | 27.0 (25.9; 28.1) | 29 | 26.8 (25.7; 27.9) | 24 | |
| 6 months | 26.9 (25.5; 28.9) | 16 | 27.2 (25.8; 28.6) | 16 | 27.5 (25.8; 21.2) | 31 | 27.1 (25.9; 28.1) | 24 | |
|
| |||||||||
| Peak (nM) | 0.550c, 0.245d, 0.522e | ||||||||
| Baseline | 301 (264; 339) | 16 | 309 (263; 354) | 18 | 307 (285; 330) | 30 | 283 (256; 313) | 22 | |
| 3 months | 306 (274; 338) | 15 | 327 (288; 365) | 16 | 299 (273; 325) | 29 | 289 (263; 314) | 24 | |
| 6 months | 329 (289; 368) | 16 | 321 (276; 367) | 16 | 300 (271; 328) | 31 | 303 (278; 327) | 24 | |
|
| |||||||||
| Lag time (min)a | 0.727c, 0.845d, 0.799e | ||||||||
| Baseline | 3.40 (3.11; 3.71) | 16 | 3.17 (2.87; 3.49) | 18 | 3.26 (3.00; 3.53) | 30 | 3.29 (2.91; 3.72) | 22 | |
| 3 months | 3.39 (2.85; 3.44) | 15 | 3.13 (2.85; 3.42) | 16 | 3.16 (2.91; 3.45) | 29 | 3.34 (2.98; 3.75) | 24 | |
| 6 months | 3.26 (2.97; 3.58) | 16 | 3.15 (2.82; 3.53) | 16 | 3.15 (2.86; 3.27) | 31 | 3.25 (2.92; 3.62) | 24 | |
|
| |||||||||
| Velocity index (nM/min) | 0.398c, 0.155d, 0.372e | ||||||||
| Baseline | 99 (82; 116) | 16 | 107 (79; 134) | 18 | 111 (96; 127) | 30 | 91 (74; 106) | 22 | |
| 3 months | 106 (89; 122) | 15 | 114 (92; 135) | 16 | 109 (91; 128) | 29 | 91 (76; 105) | 24 | |
| 6 months | 112 (86; 138) | 16 | 124 (88; 160) | 16 | 104 (90; 118) | 31 | 103 (88; 117) | 24 | |
|
| |||||||||
| F1 + 2 (pmol/l)a | 0.474c, 0.611d, 0.758e | ||||||||
| Baseline | 196 (149; 260) | 16 | 212 (184; 245) | 17 | 212 (184; 245) | 30 | 174 (138; 218) | 22 | |
| 3 months | 207 (169; 254) | 14 | 198 (164; 240) | 16 | 198 (164; 240) | 30 | 207 (161; 265) | 24 | |
| 6 months | 174 (140; 216) | 16 | 223 (184; 271) | 16 | 223 (184; 271) | 30 | 182 (149; 222) | 23 | |
|
| |||||||||
| D-dimer (µg/l)a | 0.622c, 0.439d, 0.795e | ||||||||
| Baseline | 0.26 (0.21; 0.32) | 16 | 0.31 (0.25; 0.39) | 18 | 0.29 (0.25; 0.34) | 30 | 0.26 (0.21; 0.30) | 23 | |
| 3 months | 0.27 (0.21; 0.35) | 15 | 0.28 (0.21; 0.34) | 16 | 0.27 (0.23; 0.31) | 30 | 0.30 (0.25; 0.37) | 24 | |
| 6 months | 0.23 (0.19; 0.29) | 16 | 0.29 (0.23; 0.32) | 18 | 0.27 (0.23; 0.31) | 31 | 0.25 (0.21; 0.30) | 24 | |
Data are unadjusted mean (95% CI) or ageometric mean (geometric 95% CI); bnumber of samples available for analysis; cp values for interactions between the group and time; dp values for main effects of time for all groups combined; ep values for between-group effects; CON, control group; BIKE, active commuting exercise group; MOD, moderate-intensity leisure-time exercise group; VIG, vigorous-intensity leisure-time exercise group; BMI, body mass index; ETP, endogenous thrombin potential; F1 + 2, prothrombin fragment 1 + 2.