Table 1.

Types of treatment for masculinisation and feminisation [15]

Aim	Type of Preparation	Notes	Recommendations
Medications for masculinisation	Testosterone preparations	Include testosterone injections and transdermal gels	Avoid smoking (risk of thrombosis)
	Medications to suppress hyptolamic-pituitary-gonadal activity		Avoid smoking (risk of thrombosis)
Medications for feminisation	Estradiol preparations	Doses necessary to achieve serum estradiol levels typical of pre-menopausal woman. Include oral estradiol and transdermal estradiol as patches and gels (for people over 40 years old). Ethinylestradiol will not be recommended	Avoid if Body Mass Index > 40; avoid smoking (risk of thrombosis)
	Medications to suppress hypothalamic-pituitary-gonadal activity and endogenous testosterone release	Include gonadotropin releasing hormone analogues and 5-alpha reductase inhibitors	Avoid if Body Mass Index > 40; avoid smoking (risk of thrombosis)
	Ornithine decarboxylase inhibitors	May be recommended as an adjunct to facial hair reduction interventions	Avoid smoking (risk of thrombosis)