Table 2.

Recent reported structures with BACE1 inhibitory activity.

Scaffold	In vitro activity	Reference	Scaffold	In vitro activity	Reference
	BACE1 IC50 = 7.90 μM %inhibition BACE1 at 10 μM = 61.90%	Jain et al., 2016a		BACE1 IC50 = 6.42 μM %inhibition BACE1 at 10 μM = 78.23%	Jain et al., 2016b
	BACE1 IC50 = 0.12 μM PC12-APPSW Cell IC50 = 1.7 μM BACE2 IC50 = 8.9 μM %inhibition CatD at 10 μM = 5.7% CatD IC50 >> 10 μM	De Tran et al., 2016		BACE1 IC50 = 3.7 μM %inhibition BACE1 at 10 μM = 66.0%	Haghighijoo et al., 2017
	BACE1 IC50 = 4.6 μM %inhibition BACE1 at 10 μM = 84.5 %	Yan et al., 2017		BACE1 Ki = 4.38 nM BACE1 IC50 = 2.84 μM %inhibition BACE1 at 10 μM = 61.32%	Azimi et al., 2017
	BACE1 Ki = 12 nM	Ghosh et al., 2017