Table 1.
Cytokine profile induced by EBV-dUTPase peptide L83-K103 in human a PBMCs at 48 h.
| Treatments (10 µg/mL) | IL-6 (pg/mL) |
IL-1β (pg/mL) |
TNFα (pg/mL) |
IL-8 (pg/mL) |
IL-10 (pg/mL) |
|---|---|---|---|---|---|
| Untreated | 5 ± 0.8 | 31 ± 22.8 | 5 ± 4.9 | 407 ± 5.7 | 8 ± 3.8 |
| EBV-dUTPase | 9570 ± 5.7 | 978 ± 15 | 379 ± 123 | 35,039 ± 219 | 311 ± 35 |
| Scrambled peptide L83-K103 | 369 ± 312 | 34 ± 24.4 | 9 ± 6.2 | 8738 ± 267.6 | 9 ± 5.2 |
| EBV-dUTPase peptide L83-K103 | 3272 ± 6 | 111 ± 21.5 | 45 ± 6.6 | 21,934 ± 14 | 43 ± 6.2 |
a PBMCS from healthy donors were treated with EBV-dUTPase full-length protein, EBV-dUTPase peptide L83-K103, scrambled control peptide (10 µg/mL), or left untreated for 48 h. Culture supernatants were collected for cytokine analysis by ELISA. Cytokine levels are expressed as pg/mL. Values represent mean ± SD of an n = 3.