DIMER	the dimerization domain
EGFR	epidermal growth factor receptor
ERK	Extracellular signal-Regulated Kinase
ETS	E-Twenty-Six
FTI	farnesyltransferase inhibitors
HER2	human epidermal growth factor receptor 2
HHMI	Howard Hughes Medical Institute
IHC	Immunohistochemical
MAPK	Mitogen-Activated Protein Kinase
MEK	Mitogen-Activated Protein Kinase kinase
NCI	National Cancer Institute
NIH	National Institutes of Health
OS	overall survival
PanCAN	Pancreatic Cancer Action Network
PanIN	pancreatic intraepithelial neoplasias
PDAC	pancreatic ductal adenocarcinoma
PDEδ	phosphodiesterase δ
PDX	patient-derived xenograft
PFS	progression free survival
RAF	RAF serine/threonine kinase
RAS	rat sarcoma viral oncogene
RING	Really Interesting New Gene
RTK	Receptor Tyrosine Kinase
SBD	substrate-binding domain
SBS	substrate-binding site
SEV	Sevenless receptor, the Drosophila homolog of mammalian EGFR membrane receptor
SIAH	Seven-In-Absentia Homolog
SINA	Seven-In-Absentia
SOC	standard of care
SOS	Son of Sevenless
SZF	SIAH-type zinc finger
TME	Tumor Microenvironment