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. 2018 May 17;10(5):144. doi: 10.3390/cancers10050144

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Temozolomide (TMZ) enhances oncolytic adenovirus (OAd)-mediated cytopathic effect (CPE) through increased viral replication: (A) Human triple-negative breast cancer (TNBC) cells were infected with OAdmCherry or adenovirus expressing green fluorescent protein (AdGFP) at a multiplicity of infection concentration of 2.5 alone or in combination with either dimethyl sulfoxide (DMSO) or TMZ. At 72 h post infection, crystal violet staining was used to evaluate CPE. A representative staining is shown of three experiments performed. (B) OAd-mediated CPE was calculated by measuring the absorbance of solubilized dye at 590 nm. Results represent the mean of three repeated measurements ± standard deviation (SD; error bars) (* p < 0.05). (C) Supernatants were collected and used to determine adenovirus yield from each cell line. Results represent the mean of three repeated measurements ± standard deviation (SD; error bars) (* p < 0.05).