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. 2018 Apr 24;9(5):226. doi: 10.3390/genes9050226

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Progression-free survival in multiple myeloma (MM) patients with respect to BSG SNPs. Panels (a,b) show survival for rs4919859 C and rs8637 G, respectively. The two SNPs, located in a presumed transcription factor and microRNA binding sites, are in low/medium LD. Given their similar effect on progression-free (PFS), an rs4919859 C and rs8637 G (or CG, in short) haplotype was also tested for association with PFS, and is shown in panel (c). Curves to the left show PFS calculated for the entire group of patients, while those to the right show PFS calculated for the subgroup of thalidomide-treated patients. The numbers at risk show numbers of patients in the risk set (i.e., patients without disease progression, a number used to calculate survival) at a given time point on the x-axis. Survival was calculated using the Kaplan-Meier method and the real statistics resource pack for Microsoft excel 2013 (Microsoft).