Table 3.
Association test of the best two single nucleotide polymorphism (SNP) candidates: rs201967957 (G/A) located in gene MEIS1 (chromosome 2) and rs576099063 (G/T) located in gene TSPAN15 (chromosome 10). The table shows results for comparisons of cases versus different control groups, namely, 1000G-IBS, 1000G-GBR, 1000G-TSI, all these 1000G controls merged in a single group (abbreviated as ‘1000G-ALL’).
| Cohort | Statistical Values | rs201967957 (G/A) | rs576099063 (G/T) |
|---|---|---|---|
| Cases | AF | 0.9375 | 0.8125 |
| 1000G-IBS | MAF | 0.09346 | 0.1402 |
| OR | 145.50 | 26.58 | |
| p-value | 3.71 × 10−13 | 2.36 × 10−8 | |
| 1000G-CEU | MAF | 0.13920 | 0.08763 |
| OR | 92.78 | 45.12 | |
| p-value | 4.40 × 10−11 | 3.07 × 10−1 | |
| 1000G-GBR | MAF | 0.08989 | 0.15730 |
| OR | 151.90 | 23.21 | |
| p-value | 4.84 × 10−13 | 1.05 × 10−7 | |
| 1000G-TSI | MAF | 0.1557 | 0.1179 |
| OR | 81.36 | 32.41 | |
| p-value | 1.34 × 10−1 | 4.22 × 10−9 | |
| 1000G-ALL | MAF | 0.12 | 0.1262 |
| OR | 109.90 | 29.99 | |
| p-value | 6.05 × 10−13 | 1.60 × 10−9 |
AF: allele frequency in cases that is minor in controls; MAF: minor allele frequency; OR: odds ratio.