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. 2018 May 7;9(5):243. doi: 10.3390/genes9050243

Figure 1.

Figure 1

Complex I subunits involved in tumor biology. (A) Mammalian respiratory complex I (CI) structure based on the structure reported by Fiedorczuk et al. [15], (PDB ID: 5LNK). Different functional modules (NADH (N), quinone (Q) and proton-pumping (P) modules) are shown in shades of blue. The P-module is divided in Pp (proximal P module) and Pd (distal P module) following the most recent nomenclature [2]. (B) The CI nuclear subunits that have been found differentially expressed in tumors compared to normal tissues or cells. Downregulated subunits are highlighted in shades of purple, while NDUFS8, the only subunit found upregulated is colored red. (C) Mitochondrial DNA encoded subunits (ND1-6 and ND4L) of the membrane arm. Amino acid substitutions induced by missense mutations reported in the text and involved in tumor biology are shown as spheres and are colored red.