Table 1. . A PICO table illustrating the systematic review question and criterion.

Review question	Is there a role for KDs in the therapeutic management of adult and paediatric gliomas?
Population	Adults and children with glioma tumors following a KD
Intervention	Any form of KD, with KD defined as a diet that is designed to produce ketones
Outcomes	Objective or self-reported measures are acceptable for the following outcomes: Primary outcomes: • Overall survival • Progression-free survival	Secondary outcomes: • Adverse events • Retention rates • Quality of life • Acceptability • Tolerability • Compliance • Duration of KD • Time of dietary commencement (in relation to treatment pathway) • Ketone levels • Glucose levels
Setting	Primary, secondary or tertiary healthcare. Inpatient, outpatient or community settings
Study design	All

KD: Ketogenic diet.