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Z-average diameter (nm) and Zeta potential (mV) values of lipoplexes at different N/P molar ratios. Formulations DOTAP/Chol/DOPE 1/0.75/0.5, DOTAP/Chol/DOPE 1/0.5/0.5, DOTAP/DOPE 1/1 and DC-Chol/DOPE 1/1 were complexed to siCR at 100nM at N/P ratios of 0.5, 1.25, 2.5, 5, 7.5 and 10 (n = 4). The siRNA binding ability of lipoplexes was also evaluated by agarose gel retardation assay for all same formulations. The N/P 0 represents free siRNA.
