Table 3.
No of rats | Dose (mg/kg) | Mortality |
---|---|---|
1ST PHASE | ||
3 | 175 | 0/3 |
3 | 350 | 0/3 |
3 | 700 | 0/3 |
2ND PHASE | ||
2 | 625 | 0/2 |
2 | 1250 | 0/2 |
2 | 2500 | 0/2 |
2 | 5000 | 0/2 |
Least dose that killed a rat = nil; Highest dose that did not kill any rat = 5000 mg/kg. Therefore, oral LD50 of AEVAL is >5000 mg/kg in Wistar rats.