Table 1.
Clinical, demographic, and neuropathological characteristics by diagnostic category.
| Clinical Diagnosis | ||||||
|---|---|---|---|---|---|---|
| CTL (N=9) |
sAD (N=8) |
fAD (N=8) |
P-value | Pair-wise comparison | ||
| Age (years) at death: | Mean ± SD (Range) |
71.1 ± 5.9 (55–91) |
68.9 ± 4.2 (53–75) |
52.8 ± 7.1 (37–65) |
<0.01a | (CTL, sAD) > fAD |
|
| ||||||
| MMSE: | Mean ± SD (Range) |
27.1 ± 1.9* (25–30) |
11.6 ± 3.4* (4–17) |
12.1 ± 5.1** (0–16) |
<0.0001a | CTL > (sAD, fAD) |
|
| ||||||
| Post-mortem interval (hours): | Mean ± SD (Range) |
8.1 ± 3.3 (6.0–11.4) |
8.4 ± 2.8 (4.8–12.6) |
11.5 ± 4.5 (7.7–17.3) |
0.2a | – |
|
| ||||||
| Distribution of Braak scores: | 0 | 0 | 0 | 0 | <0.001a | (sAD, fAD) > CTL |
| I/II | 4 | 0 | 0 | |||
| III/IV | 5 | 2 | 1 | |||
| V/VI | 0 | 6 | 7 | |||
*
3 cases and
**
4 cases did not have scores available for this test
a
Kruskal-Wallis test, with Bonferroni correction for multiple comparisons.