Table 1a.
Results of adjusted logistic regression analyses of the associations between increasing number of medications and risk of fall a
| Systemically active medications OR (95%CI) |
Non-antiretroviral medications OR (95%CI) |
Sedating medications b OR (95%CI) |
Non-sedating medications b OR (95%CI) |
|
|---|---|---|---|---|
| Unadjusted | 1.12 (1.05, 1.18) | 1.13 (1.06, 1.20) | 1.36 (1.14, 1.62) | 1.05 (0.98, 1.14) |
|
| ||||
| Age | 0.98 (0.94, 1.02) | 0.98 (0.95, 1.02) | 1.00 (0.95, 1.04) | ---- |
|
| ||||
| Each additional medication | 1.12 (1.06, 1.19) | 1.13 (1.06, 1.21) | 1.36 (1.13, 1.63) | 1.06 (0.97, 1.15) |
|
| ||||
| Sex (female vs male) | 1.48 (0.73, 3.03) | 1.44 (0.70, 2.94) | 1.38 (0.67, 2.87) | --- |
|
| ||||
| Each additional medication | 1.11 (1.04, 1.18) | 1.12 (1.05, 1.19) | 1.35 (1.13, 1.61) | 1.05 (0.97, 1.14) |
|
| ||||
| Race | ||||
| Hispanic vs Black | 0.76 (0.29, 1.97) | 0.76 (0.29, 1.97) | 0.62 (0.23, 1.67) | --- |
| White vs Black | 1.65 (0.74, 3.68) | 1.55 (0.70, 3.46) | 1.20 (0.51, 2.83) | --- |
|
| ||||
| Each additional medication | 1.12 (1.05, 1.19) | 1.12 (1.05, 1.20) | 1.36 (1.13, 1.64) | 1.06 (0.98, 1.14) |
|
| ||||
| Charlson comorbidity Index | 0.90 (0.76, 1.06) | 0.90 (0.77, 1.07) | 0.93 (0.79, 1.10) | --- |
|
| ||||
| Each additional medication | 1.14 (1.06, 1.22) | 1.15 (1.07, 1.23) | 1.36 (1.14, 1.62) | 1.07 (0.98, 1.17) |
|
| ||||
| Alcohol use c | ||||
| Did not exceed daily/weekly limits vs no alcohol | 0.46 (0.12, 1.75) | 0.46 (0.12, 1.76) | 0.57 (0.15, 2.21) | --- |
| Exceeded daily/weekly limits vs no alcohol | 1.36 (0.63, 2.95) | 1.34 (0.62, 2.90) | 1.37 (0.63, 3.02) | --- |
|
| ||||
| Each additional medication | 1.12 (1.05, 1.19) | 1.13 (1.05, 1.20) | 1.34 (1.12, 1.61) | 1.06 (0.98, 1.15) |
|
| ||||
| Ilicit or misused prescription opioid, any d | 1.26 (0.56, 2.83) | 1.24 (0.55, 2.80) | 1.13 (0.49, 2.62) | --- |
| Each additional medication | 1.12 (1.05, 1.19) | 1.12 (1.06, 1.20) | 1.36 (1.14, 1.62) | 1.05 (0.98, 1.14) |
|
| ||||
| Non-prescribed sedative medication use, any d | 2.03 (0.67, 6.12) | 1.97 (0.65, 5.91) | 1.84 (0.60, 5.61) | --- |
|
| ||||
| Each additional medication | 1.12 (1.05, 1.19) | 1.13 (1.06, 1.20) | 1.36 (1.14, 1.62) | 1.06 (0.98, 1.14) |
|
| ||||
| Cocaine, any d | 1.50 (0.72, 3.13) | 1.46 (0.70, 3.03) | 1.44 (0.68, 3.03) | --- |
|
| ||||
| Each additional medication | 1.12 (1.05, 1.18) | 1.12 (1.05, 1.20) | 1.36 (1.14, 1.62) | 1.05 (0.98, 1.14) |
Results of separate logistic regression models examining the association of the number of medications in each category and fall/accident controlling for each covariate listed above. Each regression model included the number of medications and one covariate. Analyses used study entry data. The first odds ratio (95% CI) in each row is the parameter estimate for the covariate. The second OR is the parameter estimate for the number of medications in each category. Bolded numbers indicate statistically significant association (p<0.05)
Results of one model “number of sedating medications”,” number of non-sedating medications” and one covariate
NIAAA defined drinking limits (> 14 drinks in a week or 5+ drinks in a day, for men; or >7 drinks in a week or 4+ drinks in a day, for women)
Past 30 days