Fig. 4.

FA exposure increases the collagen production of fibrotic mice. Groups of mice were submitted to bleomycin injection (1.5 U/kg, orotracheal route) and after 7 days were exposed to FA inhalation (0.75 ppm, 1 h/day, 15 days). Non-manipulated animals were used to basal parameters. After 24 h of last exposure to FA or 14 days after fibrosis development, the collagen production was evaluated. Data represent the mean ± SEM of 6 animals. *P < 0.05 compared to the B group; ^θP < 0.05 compared to the F group; ^δP < 0.05 compared to the FA group. Panels A, B, C and D represent the basal, fibrosis, FA and FA + fibrosis groups respectively.