Fig. 10.

Rat brain in the nucleus caudatus area (hematoxylin-eosine stain, magnification *400). (a) A control rat. The neuron nuclei are predominantly spherical, with well-visible eosinophilic granulosity (arrow 1), and notable nucleoli in the center (arrow 2). (b) A rat exposed to subchronic i.p. intoxication with CuO-NPs. Arrows point to: poorly stained neuron nuclei, with an indistinct membrane (1), nucleoli that are pycnotic (2), often absent (3) or shifted towards the nuclear membrane (4). First published in [79].