Fig. 12.

The isobologram of a three-factorial toxicity case classified as “B”: the additivity of the [PbO-NP + CuO-NP] binary unidirectional action on the thrombocrit index in the absence of any other toxic exposure (left) transforms into a contra-directional (opposite) action of the same two Me-NPs against concomitant background exposure to ZnO-NPs (right). The doses of PbO and CuO are plotted on the axes in mg per rat. The numbers at the lines of the isoboles show the values of the effect. First published in [64].