Table 3.
Ketogenic and control mouse indices
| Baseline IOP (mmHg) | Terminal IOP (mmHg) | Baseline weight (g) | Terminal weight (g) | Food intake by week (g) | kCal by week | Plasma βHB levels (mm) | Retina βHB levels μg/μg of protein | |
|---|---|---|---|---|---|---|---|---|
| D2 keto | ||||||||
| Male (n = 14) | 16.8 ± 1.2 | 18.0 ± 0.7 | 36.2 ± 1.0 | 41.9 ± 1.1 | 17.4 ± 0.6 | 117 ± 1.1 | 0.50 ± 0.02 | 0.2008 ± 0.00065 n = 8 retina |
| Female (n = 10) | 16.8 ± 1.2 | 18.1 ± 1.7 | 27.6 ± 1.1 | 31.4 ± 1.1 | 12.2 ± 0.5 | 82.64 ± 1.0 | 0.4 ± 0.03 | |
| D2 control | ||||||||
| Male (n = 12) | 17.1 ± 0.7 | 16.9 ± 0.7 | 37.2 ± 1.1 | 37.9 ± 1.1 | 29.9 ± 0.7 | 117 ± 1.5 | 0.08 ± 0.003 | 0.0029 ± 0.00014 n = 4 retina |
| Female (n = 12) | 17.1 ± 0.8 | 16.8 ± 0.9 | 26.3 ± 1.0 | 26.0 ± 1.0 | 20.4 ± 13 | 80.1 ± 1.1 | 0.10 ± 0.003 | |
| D2G keto | ||||||||
| Male (n = 5) | 12.1 ± 0.8 | 12.1 ± 0.5 | 32.9 ± 2.2 | 37.2 ± 1.2 | 16.5 ± 0.5 | 111.5 ± 2.0 | 0.2 ± 0.020 | |
| Female (n = 2) | 12.2 ± 0.4 | 11.9 ± 0.1 | 24.3 ± 2.1 | 27.0 ± 1.0 | 11.5 ± 2 | 77.8 ± 1.5 | ||
| D2G control | ||||||||
| Male (n = 2) | 11.9 ± 0.8 | 12.1 ± 0.8 | 32.1 ± 0.9 | 32.5 ± 1.0 | 28.8 ± 2 | 112 ± 1.0 | 0.07 ± 0.001 | |
| Female (n = 2) | 12.1 ± 0.2 | 12.0 ± 0.5 | 24.6 ± 0.5 | 24.5 ± 0.9 | 20.2 ± 13 | 79.2 ± 1.1 |
n = Number of mice. Numbers are averages per mouse; all values are the mean ± SEM.