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Representative low-power magnification of 6E10-immunopositive Aβ plaques in the cingulate cortex of a APPswe/PS1 (A) and a APPswe/PS1/hCOX-2 transgenic (B), respectively. In (C) and (D), low-power magnification of Congo Red-positive Aβ plaque in the cerebral cortex of a APPswe/PS1 and a APPswe/PS1/hCOX-2 mouse displaying birefringence under polarized light. Scale bars (A, B): 100 μm; (C, D): 30 μm.
