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. 2018 May 30;10:72. doi: 10.1186/s13148-018-0505-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Levels of DNA epigenetic modifications—5-mdC (a), 8-oxodG (b), 5-hmdC (c), 5-fdC (d), 5-cadC (e), and 5-hmdU (f) in normal colonic tissue (n = 90); inflammatory lesions, IBD (n = 49); polyps, AD (n = 39); and cancer tissue, CRC (n = 97). Marker in the center of the box represents median value. The length of each box (IQR, interquartile range) represents the range of values for 50% of the most typical observations, and its edges correspond to the first and third quartile. Whiskers represent variance outside the upper and lower quartile. P value was determined with Mann-Whitney U test