Figure 3.

Comparison of AE severity definitions in CTCAE and OAE. (A) CTCAE term ‘Skin ulceration’ and its five grades. (B) OAE term ‘Skin ulceration’, all its child terms, and related axioms. Ontofox was used to extract all children under ‘skin ulceration AE’ and all their related terms and axioms from OAE. The Ontofox output was displayed in Protégé OWL editor, and the screenshot was taken from the display. The OAE annotation includes its mapping to CTCAE ontology term ID. The linkage of the OAE term to the AE severity grade is logically defined using the new relation ‘has participant quality’. The ulcer diameter is included in another axiom to specify the Grade 2 severity. OAE does not include ‘Grade 5 skin ulceration AE’ as explained in the text.