Fig. 8.

STARD13-correlated ceRNA network enhances the sensitivity of breast cancer cells to doxorubicin. a Representative profile of side population (SP) fractions of MDA-MB-231 cells with STARD13-correlated ceRNAs-3′UTR overexpression stained with Hoesch 33342. b IC₅₀ curves of MDA-MB-231 cells with STARD13-correlated ceRNAs-3′UTR overexpression and were fitted with a nonlinear regression model and were presented as log (doxorubicin) vs. cell viability. c Pgp protein expression was detected in cells described in a. d Confocal images of MDA-MB-231 cells described in a with doxorubicin treatment. Overexpression of STARD13-correlated ceRNAs-3′UTRs promoted the cellular retention of doxorubicin. e Images of tumors harvested when STARD13-correlated ceRNA stable knockdown cells were planted and followed by doxorubicin treatment or not. f The volume of tumors harvested in e was monitored. g The weight of tumors harvested in e was monitored. h The weight of mice depicted in e was monitored. Data were presented as the mean ± SD, n = 3, **p < 0.01 vs. pLVX-Ctrl