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. 2018 May 30;11:72. doi: 10.1186/s13045-018-0613-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 9 — Proposed model that STARD13-correlated ceRNA network inhibits breast cancer EMT and CSC formation, and thus drug resistance. STARD13-correalted ceRNA network acts as a potential inhibitor of YAP transcriptional activity at least through two concurring pathways: one is by facilitating LATS1/2 expression via ceRNA interaction and the other is by blocking RhoA-F-actin signaling cascade through Rho GTPase activity of STARD13. This inhibition results in EMT prohibition and inhibits breast CSC formation, and thus enhances drug sensitivity