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. 2018 May 30;18:45. doi: 10.1186/s12866-018-1186-8

Fig. 4.

Fig. 4

IgG-levels against the indicated R. pneumotropicus antigens in intranasally infected BALB/c (a) and C57BL/6 (b) mice and the respective contact and bedding sentinels in sera drawn at the indicated time points. A serum pool from mice naturally infected with R. pneumotropicus was used as reference serum. The culture supernatant had a concentration factor of 100. Early losses refer to mice killed for animal welfare reasons after developing severe signs of sepsis. Statistical analysis with the Mann-Whitney test was performed to analyse differences between the different groups. The Wilcoxon test was used to compare different time point values within the same groups. The star in panel (b) (whole cell extract) indicates significance (* for P ≤ 0.05)