Table 3.
Predictors at enrollment of a suboptimal HRQoL at the 36-month follow-up
| Predictors | PedsQL score of suboptimal HRQoL at the 36-month follow up | |||
|---|---|---|---|---|
| Total < 79.3 | Physical health < 84.4 | Psychosocial health < 73.3 | ||
| Univariate | Multiple | Multiple | Multiple | |
| Agea | 1.01 (0.97–1.05) | 1.02 (0.97–1.07) | 1.06 (1.02–1.11)** | 1.04 (0.99–1.09) |
| Sexb | 1.01 (0.70–1.45) | 0.57 (0.38–0.85)** | ||
| SES score | 0.97 (0.92–1.03) | |||
| Time between symptom onset and diagnosis | 1.01 (1.00–1.03) | |||
| Uveitis | 0.86 (0.41–1.66) | |||
| JIA categories | ||||
| Persistent oligoarthritis | Referent | |||
| Extended oligoarthritis | 1.58 (0.91–2.71) | |||
| RF-negative polyarthritis | 1.10 (0.69–1.73) | |||
| RF-positive polyarthritis | 2.24 (0.63–7.22) | |||
| Psoriatic arthritis | 1.53 (0.66–3.36) | |||
| Enthesitis-related arthritis | 0.95 (0.48–1.80) | |||
| Systemic-onset JIA | 1.22 (0.42–3.12) | |||
| Undifferentiated arthritis | 0.80 (0.34–1.71) | |||
| Disease activity | ||||
| cJADAS-10 | 1.03 (1.00–1.06)* | |||
| PGA | 1.02 (0.96–1.09) | |||
| Parent’s global | 1.19 (1.10–1.29)*** | 1.15 (1.05–1.26)** | 1.14 (1.03–1.26)** | |
| Active joint count | 1.00 (0.97–1.02) | |||
| Pain | ||||
| Numeric rating scale | 1.14 (1.07–1.22)*** | 1.21 (1.13–1.30)*** | ||
| Functional ability | ||||
| CHAQ | 1.74 (1.36–2.23)*** | |||
| Psychosocial burden of families | ||||
| FaBel total | 4.82 (2.96–7.98)*** | 3.88 (2.27– 6.72)*** | 2.97 (1.78–5.02)*** | 3.63 (2.04–6.53)*** |
*p < 0.05, **p < 0.01, ***p < 0.0001
CHAQ, Childhood Health Assessment Questionnaire; cJADAS-10, clinical Juvenile Arthritis Disease Activity Score; FaBel, Family Burden Questionnaire; HRQoL, health-related quality of life; JIA, juvenile idiopathic arthritis; PedsQL, Pediatric Quality of Life Inventory; PGA, physician’s global assessment of disease activity; RF, rheumatoid factor; SES, socioeconomic status
a Admitted to multivariate analyses to adjust for missing data
b Female referent