Fig. 2. PHIP(2) (green sticks and ribbons) in complex with NMP (cyan sticks). The substitution of an Asn for the smaller Thr allows an extra water molecule, the PHIP water (red CPK, PW) to fill the space between T1396 and the usual four Brd waters (red CPK I–IV) (PDB ID: 3MB3).1.