Fig. 4. Design of DSPL1 (A) scaffolds used to identify poised fragments. Core scaffolds based upon the most commonly used medicinal chemistry reactions as described by Roughley and Jordan.32 Heterocycle scaffolds based on reactions described by Hartenfeller et al.37 (B) Poised reaction motif vs. cluster. Circle size represents the number of compounds in each group. 407 compounds for DSPL1 were selected from all SGC poised fragments based on diversity and poised reaction motif.
