Fig. 6. PHIP(2) (green sticks and ribbons) in complex with N-benzylacetamides 12–14 (cyan sticks). Electron density shown as green and blue mesh (2Fo-Fc). (A) The amide 12 binds in the same pose as fragment hit 2. (B) The hydroxyacetamide 13 forms an H-bond to P1340. (C) Tertiary amide 14 appears to displace structural water II.