Table 4.

Effect of mutating the Zα and Zβ domains of ADAR1

	ADAR1	WAB	HAG
RG10A-E1	43 (2)	40 (4)	10 (8)
RG10A-E2	71 (4)	68 (4)	27 (3)
M14X8A	66 (6)	51 (5)	12 (7)

Mutation to the Zα and Zβ of ADAR1 lower editing of a 15-bp substrate but not that of a longer substrate containing a strong Z-forming segment. Editing by ADAR1 and WAB were compared to HAG, a catalytically inactive form of ADAR1. Quantitation for M14X8a (see Table 1 for the sequence) is based on five experiments. Quantitation of the two editing sites in RG10A (see Table 3 for the sequence) is based on three experiments. The standard deviation is shown in parentheses.