Table 4.
Effect of catechol derivatives I–IV on marker enzymes in serum, liver and kidney in control and experimental rats during subacute toxicity studies.
| Parameters | Group I | Group II | Group III | Group IV | Group V |
|---|---|---|---|---|---|
| Control | Catechol derivative I | Catechol derivative II | Catechol derivative III | Catechol derivative IV | |
| SERUM | |||||
| Aspartate amino transferase | 33.64 ± 2.50 | 32.51 ± 3.32 | 29.60 ± 2.97 | 32.14 ± 2.97 | 30.69 ± 3.61 |
| Alanine amino transferase | 25.05 ± 2.11 | 23.83 ± 2.76 | 27.33 ± 2.80 | 24.76 ± 2.78 | 26.56 ± 2.89 |
| Alkaline phosphatase | 1.77 ± 0.18 | 1.84 ± 0.20 | 1.71 ± 0.17 | 1.79 ± 0.16 | 1.82 ± 0.18 |
| LIVER | |||||
| Aspartate amino transferase | 26.11 ± 2.51 | 28.31 ± 2.39 | 27.10 ± 2.51 | 28.84 ± 2.47 | 24.91 ± 2.35 |
| Alanine amino transferase | 16.21 ± 1.73 | 15.06 ± 1.89 | 15.55 ± 1.44 | 14.65 ± 2.12 | 18.07 ± 1.70 |
| Alkaline phosphatase | 1.17 ± 0.01 | 1.22 ± 0.13 | 1.13 ± 0.01 | 1.19 ± 0.01 | 1.15 ± 0.01 |
| KIDNEY | |||||
| Aspartate amino transferase | 23.84 ± 2.21 | 24.06 ± 3.0 | 22.63 ± 2.57 | 24.27 ± 2.35 | 26.08 ± 2.79 |
| Alanine amino transferase | 12.14 ± 1.28 | 13.86 ± 1.30 | 13.65 ± 1.79 | 11.93 ± 1.03 | 12.83 ± 1.97 |
| Alkaline phosphatase | 0.74 ± 0.09 | 0.80 ± 0.10 | 0.69 ± 0.05 | 0.72 ± 0.06 | 0.83 ± 0.07 |
Values are expressed as mean ± SD for 6 animals. Aspartate amino transferase (AST) & Alanine amino transferase (ALT): μmoles × 10−2 of pyruvate liberated/min/mg/protein; Alkaline phosphatase (ALP): μmoles × 10−2 of phenol liberated/min/mg/protein. Comparisons are made between:- Group I with Groups II, III, IV and V. The symbol * also represent the statistically significance at p < .05.