Table 5.
Effect of catechol derivatives I–IV on lipid profile in serum, liver and kidney in control and experimental rats during subacute toxicity studies.
| Parameters | Group I | Group II | Group III | Group IV | Group V |
|---|---|---|---|---|---|
| Control | Catechol derivative I | Catechol derivative II | Catechol derivative III | Catechol derivative IV | |
| SERUM (mg/dl) | |||||
| TC | 86.98 ± 6.46 | 77.00 ± 6.14* | 82.96 ± 6.73 | 79.85 ± 6.14 | 70.01 ± 6.26* |
| TG | 115.25 ± 10.09 | 85.35 ± 8.65* | 110.33 ± 9.05 | 107.7 ± 9.75 | 82.87 ± 7.09* |
| PHOSPHOLIPIDS | 38.67 ± 4.02 | 28.22 ± 2.98* | 35.76 ± 2.86 | 36.77 ± 3.18 | 25.84 ± 3.12* |
| FFA | 27.69 ± 2.81 | 18.31 ± 1.97 | 25.75 ± 2.43 | 25.11 ± 2.45 | 16.99 ± 2.37 |
| HDL | 25.96 ± 3.15 | 29.07 ± 3.48* | 26.57 ± 2.35 | 27.38 ± 2.28 | 31.83 ± 2.94* |
| LDL | 37.94 ± 1.29 | 30.86 ± 0.93* | 36.93 ± 2.76 | 33.75 ± 2.08 | 21.60 ± 1.89* |
| VLDL | 23.05 ± 2.01 | 17.07 ± 1.73 | 19.45 ± 1.61 | 18.70 ± 1.77 | 16.57 ± 1.41 |
| LIVER (mg/gm) | |||||
| TC | 8.98 ± 0.55 | 6.28 ± 0.98* | 8.38 ± 0.48 | 8.26 ± 0.48 | 5.13 ± 0.71* |
| TG | 13.28 ± 1.67 | 8.44 ± 0.79* | 12.33 ± 1.27 | 12.59 ± 1.26 | 6.54 ± 0.59* |
| PHOSPHOLIPIDS | 20.76 ± 2.36 | 16.88 ± 1.71* | 19.21 ± 2.10 | 18.99 ± 2.31 | 14.02 ± 1.32* |
| FFA | 6.06 ± 0.52 | 4.21 ± 0.58 | 5.51 ± 0.49 | 5.41 ± 0.45 | 3.04 ± 0.53 |
| KIDNEY (mg/gm) | |||||
| TC | 5.34 ± 0.57 | 3.70 ± 0.46* | 4.84 ± 0.71 | 4.70 ± 0.63 | 3.07 ± 0.46* |
| TG | 9.15 ± 0.51 | 5.86 ± 0.79* | 8.41 ± 0.66 | 8.50 ± 0.65 | 4.43 ± 0.67* |
| PHOSPHOLIPIDS | 15.42 ± 1.65 | 13.24 ± 1.72* | 14.47 ± 1.85 | 13.64 ± 1.69 | 12.15 ± 1.36* |
| FFA | 4.84 ± 0.55 | 3.63 ± 0.44 | 4.31 ± 0.59 | 4.24 ± 0.54 | 3.05 ± 0.23 |
Values are expressed as mean ± SD for 6 animals. Comparisons are made between:- Group I with Groups II, III, IV and V. The symbol * also represent the statistically significance at p < .05.