Fig. 6.

Light micrograph of brain of male rats: (A) Control: normal histo-architecture. (B) Section of the cerebral cortex of rats treated with grape seed proanthocyanidin extract (GSPE), showing normal histology of the pyramidal cells layer and the polymorphic layer (white and green dotted arrows) and few glail cells (yellow arrow). (C1 & C2): Thalidomide and carboplatin-treated rats showing diffused gliosis (white square), dilatation of blood capillary with hemorrhage and pyknotic nuclei (blue dotted arrow), neuronal degeneration (green arrow) and encephalomelacia (yellow square) (D). Section of brain of rat treated with thalidomide, carboplatin and GSPE showing slightly restores of the neuronal cells more or less near to normal structure (black arrow) with few glail cells (yellow arrow) and residual dilatation & hemorrhage of blood vessels (blue dotted dotted arrow). (H & E, 400 X).