Table 5. Alterations detected in metastatic lymph nodes (n=6) and corresponding primary tumors.
| Patient | SNV (Primary Tumor) |
CNA (Primary Tumor) |
SNV (Metastasis) |
Allele Frequency | CNA (Metastasis) | Validation (RT-PCR) |
|---|---|---|---|---|---|---|
| G4-M | CDK6 (CN=56) ERBB2 (CN=40) CCND1 (CN=7) | CDK6 (CN=65) ERBB2 (CN=50) CCND1 (CN=8) |
Yes Yes Yes |
|||
| G13- M | PIK3CA-M1043I ERBB2-R896C JAK3-R657G |
CCND1 (CN=5) | PIK3CA-M1043I ERBB2-R896C JAK3-R657G |
33% 14% 6% |
CCND1 (CN=6.5) | Yes |
| G20-M | PIK3CA-H1047R PIK3CA-H1048Y JAK3-R657G |
PIK3CA-H1047R PIK3CA-H1048Y MET-Y1253C JAK3-R657G |
24% 38% 5% 6% |
|||
| CC28-M | KRAS-G12S EGFR-G719D NRAS-G61K |
KRAS-G12S NRAS-G61K RAF1-T421I |
32% 54% 8% |
|||
| CC30-M | RET-A883V KRAS-G12D AKT1-E17K |
KRAS-G12D RET-A883V AKT1-E17K |
30% 9.5% 11% |
|||
| CC31-M | KRAS-G13D KRAS-A146T |
PIK3CA-E365K KRAS-G13D KRAS-A146T |
17% 62.5% 1% |